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The microbial balance of our gut directly influences our Hypothalamic-Pituitary-Adrenal (HPA) axis, the production of hormones and neurotransmitters, and our immune system's regulation. Stress is very debilitating and causes depletion of magnesium because of excessive magnesium loss via the kidneys.  Magnesium deficiency causes energy depletion and acidosis, which triggers inflammatory states, resulting in moods swings, hormone imbalance, mental illnesses, fatigue, irritability, pain symptoms, and a weaker immune system. Magnesium deficiency also directly affects the beneficial bacteria, which thus leads to depressive-like behaviours.

Magnesium is an essential mineral which performs some very important functions when you're pregnant. It’s used to maintain healthy blood sugar levels in the body (see study) and it helps build healthy teeth and bones by working in partnership with calcium. It also regulates cholesterol and irregular heartbeat.

Magnesium deficiency or antagonism (blockage) can cause any one of these steps to malfunction, causing overdose of stress hormones and inability to relax enough to sleep deeply.

It's almost impossible for you to get a toxic magnesium dose or overdose, unless magnesium is given at high dose intravenously, where there is no magnesium deficiency or the person has kidney problems and can’t excrete excess salts. 

We can become addicted to more than just pharmaceutical drugs or alcohol.  Researchers are now noticing symptoms of addiction also to excessive exercise.  Does excessive exercise or over-training have negative side effects?  Could it harm health and cause premature ageing?  The research indicates yes, mainly because of increasing magnesium deficiency.

Magnesium deficiency weakens performance, stamina and increases risk of injury When you push your muscles hard your brain is telling your body to ‘squeeze’ and act. Adrenalin and cortisol increase, and that helps push the calcium into the calcium channels of the muscle fibre cells, which makes them contract. Magnesium is temporarily pushed out of these channels during the contractions. When we relax, calcium comes out and magnesium moves back into the channels to relax the muscles again. 

I was over 50 when menopause set in, accompanied by an autoimmune disorder called Hashimotos Hypothyroidism, severe heart arrhythmia, and the emerging white patches on my skin. This form of autoimmune hypothyroidism is thought to be prevalent in about 5% of the world’s population, however I believe the numbers are growing as people become more chemically sensitive to pollutants that stress the thyroid.

Note that dehydrated states can cause feelings of anxiety where we just don’t know the reason for our fear or agitation, but the feeling persists.  Re-hydrating the body with ample water and magnesium can calm down these sensations because magnesium has a dampening effect on adrenaline and cortisol.  When the brain has ample water and magnesium we can think more clearly and make better decisions.  This is especially important during crises because our magnesium reserves can become dangerously low.

Magnesium is so important to cardiovascular function, its scarcity being correlated with the development of cardiovascular disease, that it has become the focus of intense scientific study and review over recent years.  A meta-analysis review of epidemiological studies published in 2017 concluded that magnesium intake is associated with lower risk of major cardiovascular risk factors such as metabolic syndrome, diabetes and hypertension, as well as incidence of stroke and total cardiovascular disease.  Higher levels of circulating magnesium are also associated with lower risk of heart disease, mainly ischemic and coronary heart disease.

It’s been coined the master mineral and deemed as critical as water. But how exactly does it correlate to the process of ageing? The ways are numerous, but we’ll highlight a few of our standouts. From menopause to migraines, bone health to beautiful skin, you’ll be eager to lather up in magnesium cream by the time you’ve finished reading this. And remember, even if you’ve had a blood test that did not show up a deficiency in magnesium, only a small portion of magnesium stores actually sit in the blood. There are other areas more likely to be depleted that won’t be detected so simply.

Healthy cells need lipid protection, magnesium charge and ample hydration to support mitochondrial energy metabolism of Mg-ATP ‘batteries’.  This energy is then used to assemble amino acids into the various proteins we need to build collagen structures.  It is also used to manufacture hormones, enzymes, neurotransmitters and other chemical messengers.

The review goes on to explain glyphosate’s mechanism of toxic action. Firstly, it is a strong chelating agent, creating complexes that immobilize the mineral micronutrients of the soil, such as magnesium, calcium, iron, manganese, nickel and zinc, making them unavailable to plants. This means that the food supply is robbed of vital mineral nutrients. We eat the food, it fills a void, but it doesn’t supply valuable nutrition. The end result is that we keep eating more and more empty carbs until obesity and other metabolic diseases such as hypertension, diabetes, senile dementia, inflammatory bowel disease, renal failure, thyroid or liver cancer develop.

Inflammation and pain can be part of a healing crisis, but if your magnesium status is healthy you will heal and recover relatively quickly because the metabolism can perform the way it should. The lower the cellular magnesium levels get however, the slower it becomes to recover from the stresses and the more painful and amplified are the symptoms.

Premature ageing is usually marked by excessive weight gain (especially adipose tissue around the middle), exaggerated dehydration, hypercalcemia, joint stiffening, acidosis and inflammation.  In other words, getting overweight, dry and stiff with creaky and brittle bones before our time. Skin can also get very dry and saggy looking. As we need magnesium to synthesise collagen proteins and elastin fibres, which are the structures that hold us together as skin, bone, ligaments, sinew, smooth muscle walls in arteries etc, low magnesium means those structures lose their integrity. [6]  Thus magnesium helps us to stay more hydrated, flexible and stretchy longer!

Did you know that our gut microbiome needs a good supply of magnesium for energy to do all their jobs properly? Beneficial gut bacteria are extremely important to good health.  Did you know that we rely on our gut microbiome more than our own cells and enzymes for digestion of food and nutrient absorption?  If digestion is compromised we can be short-changed on magnesium uptake. Low magnesium can lead to feelings of depression, mood disorders, fatigue, restless and disturbed sleep, foggy brain, anxiety and much more.  See the STUDY: "Dietary magnesium deficiency alters gut microbiota and leads to depressive-like behaviour."

Transdermal magnesium absorption means that magnesium ions (electrolytes) can pass into the epidermis (outer layer) of the skin, which acts as a nutritional reservoir until the tiny capillaries of the dermis underneath can absorb nutrients as required. From this skin reservoir the body may also absorb the vitamin D it made when you got some sunshine on your skin.